Casein phosphopeptide stabilised amorphous calcium phosphate (CPP-ACP) has been shown to
remineralise enamel subsurface lesions. The aim of this study was to determine the effect of a paste containing 10
CPP-ACP (Toothmousse; GC) on enamel surface microhardness in vitro.
Thirty enamel blocks
(3x2 mm) were prepared for the study group from the buccal surface of extracted teeth. The microhardness of the enamel
surface was determined for the specimens initially before artificial demineralisation. After demineralization the specimens
were incubated in 10 CPP-ACP for 5 min. Artificial saliva was used as a remineralising solution for the control group.
The mean baseline surface microhardness analyses of enamel blocks were 318.6125.75 and
262.4926.82. The data show that after demineralisation the mean microhardness decline in the experimental groups
(247.05 38.31 and 186.92 63.77). The results showed that 10 CPP-ACP (281.7926.32) was
comparable to the control (252.27 31.05) for remineralisation of enamel subsurface lesions in vitro. The highest
surface microhardness recovery (SMHR) was found for control, but the differences of SMHR between
10 CPP-ACP and control was not statistically significant (p=0.805).
From the results it can be
concluded that CPP-ACP may have positive effects on enamel remineralisation.
Vol.13 – n.2/2012
Harvard: B. Kargul, B. Altinok, R. Welbury (2012) "The Effect of Casein Phosphopeptide-Amorphous Calcium Phosphate on enamel surface rehardening. An in vitro study", European Journal of Paediatric Dentistry, 13(2), pp123-127. doi:
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