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Home Subgingival periodontal pathogens in Down syndrome children without periodontal breakdown. A...

Subgingival periodontal pathogens in Down syndrome children without periodontal breakdown. A case-control study on deciduous teeth

Authors:

  • C. Vocale
    Unit of Microbiology, Regional Reference Centre for Microbiological Emergencies (CRREM), St. Orsola Malpighi Hospital, Bologna, Italy
  • M. Montevecchi
    Department of Biomedical and Neuromotor Sciences (DIBINEM), Unit of Dental Care for Patients with Special Needs and Pediatric Dentistry, University of Bologna, Bologna, Italy
  • G. D’Alessandro
    Department of Biomedical and Neuromotor Sciences (DIBINEM), Unit of Dental Care for Patients with Special Needs and Pediatric Dentistry, University of Bologna, Bologna, Italy
  • M. Gatto
    Department of Biomedical and Neuromotor Sciences (DIBINEM), Unit of Dental Care for Patients with Special Needs and Pediatric Dentistry, University of Bologna, Bologna, Italy
  • G. Piana
    Department of Biomedical and Neuromotor Sciences (DIBINEM), Unit of Dental Care for Patients with Special Needs and Pediatric Dentistry, University of Bologna, Bologna, Italy
  • L. Nibali
    Periodontology Unit, Centre for Host-Microbiome Interactions, Faculty of Dentistry and Oral Craniofacial Sciences, King´s College London, London, United Kingdom
  • M. C. Re
    Unit of Microbiology, Department of Medical and Surgical Sciences, “Alma Mater Studiorum” University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy
  • V. Sambri
    Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy

DOI:

https://doi.org/10.23804/ejpd.2021.22.04.9

ABSTRACT


Aim

Down syndrome is the most common form of aneuploidia compatible with a long survival. The affected subjects are more susceptible to severe early-onset periodontal disease and show a lower risk to develop dental caries than the non-affected population. This study investigated the prevalence of periodontal pathogens in the subgingival plaque of deciduous teeth in children with Down syndrome without signs of periodontal breakdown.

Methods

Thirty children suffering from Down syndrome and 46 matched healthy subjects were studied. A total of 228 subgingival plaque samples from deciduous teeth were separately collected and evaluated by polymerase chain reaction assays.

Results

The prevalence of Treponema denticola, Porphyromonas gingivalis, Prevotella intermedia, Aggregatibacter actinomycetemcomitans and Tannerella forsythia was investigated. Aggregatibacter actinomycetemcomitans and Tannerella forsythia were significantly more prevalent in Down syndrome children (respectively 8 and 9 times) than in controls.

Conclusion

In absence of periodontal impairment, Down syndrome children display a clear presence of periodontal pathogens already in the deciduous dentition. The hypothesis of an intrinsic predisposing condition is here supported.

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Publication date:

December /2021

Issue:

Vol.22 – n.4/2021

Page:

309 – 313

Publisher:

Ariesdue

Topic:

Children with special health care needs

Cite:


Harvard: C. Vocale, M. Montevecchi, G. D’Alessandro, M. Gatto, G. Piana, L. Nibali, M. C. Re, V. Sambri (2021) "Subgingival periodontal pathogens in Down syndrome children without periodontal breakdown. A case-control study on deciduous teeth", European Journal of Paediatric Dentistry, 22(4), pp309-313. doi: 10.23804/ejpd.2021.22.04.9
Vancouver: C. Vocale, M. Montevecchi, G. D’Alessandro, M. Gatto, G. Piana, L. Nibali, M. C. Re, V. Sambri. Subgingival periodontal pathogens in Down syndrome children without periodontal breakdown. A case-control study on deciduous teeth. European Journal of Paediatric Dentistry [Internet]. 2021Dec.20 [cited 2025May.24];22(4):309-313. Available from: https://www.ejpd.eu/abstract-pubmed/subgingival-periodontal-pathogens-in-down-syndrome-children-without-periodontal-breakdown-a-case-control-study-on-deciduous-teeth/
MLA: C. Vocale, M. Montevecchi, G. D’Alessandro, M. Gatto, G. Piana, L. Nibali, M. C. Re, V. Sambri Subgingival periodontal pathogens in Down syndrome children without periodontal breakdown. A case-control study on deciduous teeth. European Journal of Paediatric Dentistry. 2021;22(4):309-313

Copyright (c) 2021 Ariesdue

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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    Cristina Calchera
    Editor in chief: dott. Luigi Paglia
    European Journal of Paediatric Dentistry © | ISSN (Online): 2035-648X
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    European Journal of Paediatric Dentistry © | ISSN (Online): 2035-648X
    Registrazione del Tribunale di Milano n. 285 del 14.04.1998 | ROC 1946 - 26.09.2001
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