To demonstrate that the application of dental fluoride varnishes in children increases urinary fluoride
From a randomly assembled group of 42 children aged between 5 and 8 years,
residing in a community with non-fluoridated water, spot urinary samples were taken before the topical application of dental
fluoride varnish and 2 hours afterwards. In an age-matched control group of 16 children from the same community, who
received no treatment, samples were taken the same way. The urinary excretion of fluoride was analysed by determining
fluoride ion (F-) level and fluoride/creatinine (F/Cr) ratio in the urine.
In the study group, the average pre- and
post-treatment F/Cr ratios were 0.42 and 1.38 mg/g, respectively (p < .001). No significant changes were observed in the control group, which received no treatment. The average 2 hours afterward F/Cr ratios were 0.29 and 0.27 respectively (p 0.426).
The topical application of dental fluoride varnish leads to a significant increase in urine F-,
which is attributable to the application of the product.
Vol.13 – n.4/2012
Harvard: F. Garca-Hoyos, E. Barbera, P. Garca-Camba, M. Varela (2012) "Renal fluoride excretion in children following topical application of fluoride varnish", European Journal of Paediatric Dentistry, 13(4), pp280-284. doi:
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