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Home New strategies in dental caries prevention: experimental study on casein phosphopeptides

New strategies in dental caries prevention: experimental study on casein phosphopeptides

Authors:

  • G. F. Ferrazzano
    Department of Dentistry and Maxillofacial Surgery, University of Naples Federico II, Naples (Italy)
  • T. Cantile
    Department of Dentistry and Maxillofacial Surgery, University of Naples Federico II, Naples (Italy)
  • A. Ingenito
    Department of Dentistry and Maxillofacial Surgery, University of Naples Federico II, Naples (Italy)
  • L. Chianese
    Department of Nutrition, Agricultural Science Faculty, University of Naples Federico II, Naples (Italy)
  • M. Quarto
    Department of Nutrition, Agricultural Science Faculty, University of Naples Federico II, Naples (Italy)

ABSTRACT


Aim

Casein phosphopeptides (CPPs) are phosphorylated casein-derived peptides produced by proteolytic digestion of
s1-, s2- and -casein in vitro or in the digestive tract. CPPs exhibit anti-caries activity relates to their capability to localise
high levels of amorphous Ca2 phosphate on tooth surface. Aim of this study is in vitro testing of the capability of CPPs to prevent
demineralisation and promote remineralisation of early enamel lesions. MATERIALS AND METHODS 159 samples of dental enamel
were divided into 3 groups, which subsequently underwent 3 different chemical treatments: the samples from group I (control group)
were preserved in distilled water; the samples from group II were treated with a demineralising solution for producing artificial caries; the
samples from group III underwent the same treatment as group II, but with the addition of CPPs. The effects of these procedures were
evaluated by quantitative analysis (change in weight and calcium titration) and qualitative analysis (SEM). STATISTICS: Statistical
analysis of the results was performed using ANOVA. RESULTS In presence of CPPs, acid dissolution of human enamel is reduced by
over 50 in vitro. CONCLUSION Our results demonstrate that CPPs could be a valid preventive system against demineralisation
of early enamel lesions.

PLUMX METRICS

Publication date:

December /2007

Keywords:

caries, casein phosphopeptides, prevention

Issue:

Vol.8 – n.4/2007

Page:

183 – 187

Publisher:

Ariesdue

Cite:


Harvard: G. F. Ferrazzano, T. Cantile, A. Ingenito, L. Chianese, M. Quarto (2007) "New strategies in dental caries prevention: experimental study on casein phosphopeptides", European Journal of Paediatric Dentistry, 8(4), pp183-187. doi:
Vancouver: G. F. Ferrazzano, T. Cantile, A. Ingenito, L. Chianese, M. Quarto. New strategies in dental caries prevention: experimental study on casein phosphopeptides. European Journal of Paediatric Dentistry [Internet]. 2007Dec.1 [cited 2023Mar.27];8(4):183-187. Available from: https://www.ejpd.eu/abstract-pubmed/new-strategies-in-dental-caries-prevention-experimental-study-on-casein-phosphopeptides/
MLA: G. F. Ferrazzano, T. Cantile, A. Ingenito, L. Chianese, M. Quarto New strategies in dental caries prevention: experimental study on casein phosphopeptides. European Journal of Paediatric Dentistry. 2007;8(4):183-187

Copyright (c) 2021 Ariesdue

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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    European Journal of Paediatric Dentistry © | ISSN (Online): 2035-648X
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