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Home Long-term effect of anticancer therapy on dentition of Italian children in...

Long-term effect of anticancer therapy on dentition of Italian children in remission from malignant disease: A cross-sectional study

Authors:

  • R. Guagnano
    Department of Surgical Sciences, C.I.R. Dental School – Section of Pediatric Dentistry, University of Turin, Turin, Italy
  • F. Romano
    Department of Surgical Sciences, C.I.R. Dental School, Section of Periodontology, University of Turin, Turin, Italy
  • M. Berger
    Paediatric Onco-Hematology and Stem Cell Transplant Division, Città della Salute e della Scienza, Regina Margherita Children Hospital, Turin, Italy
  • F. Fagioli
    Paediatric Onco-Hematology and Stem Cell Transplant Division, Città della Salute e della Scienza, Regina Margherita Children Hospital, Turin, Italy
  • V. Vallone
    Department of Surgical Sciences, C.I.R. Dental School – Section of Pediatric Dentistry, University of Turin, Turin, Italy
  • L. Bello
    Department of Surgical Sciences, C.I.R. Dental School – Section of Pediatric Dentistry, University of Turin, Turin, Italy
  • M. C. Vitale
    Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, Section of Dentistry, Unit of Orthodontics and Pediatric Dentistry, University of Pavia, Pavia, Italy
  • P. Defabianis
    Department of Surgical Sciences, C.I.R. Dental School – Section of Pediatric Dentistry, University of Turin, Turin, Italy

DOI:

https://doi.org/10.23804/ejpd.2022.23.02.11

ABSTRACT


Aim

To investigate the effects of anticancer therapy on dental development and caries formation in Italian childhood cancer survivors compared to healthy controls.

Methods

A total of 52 children treated with chemotherapy and/or radiotherapy when younger than 10 years and in remission from at least 2 years, and 52 healthy age- and gender-matched children were consecutively enrolled in this cross-sectional study. All participants were examined for dental caries and enamel defects according to the decayed-missing-filled teeth (dmft/DMFT) index and the Aine rating scale. Panoramic radiographs were taken to estimate dental age and to assess dental abnormalities using the Höltta Defect Index.

Results

Compared to healthy controls, children in remission from malignant diseases showed increased prevalence of dental abnormalities and enamel defects in the permanent dentition, more teeth with active carious lesions and higher dental age (p <0.05). The almost totality of dental agenesis and microdontia were detected in patients treated with stem cell transplantation when younger than 5 years of age, while no difference between radiotherapy and chemotherapy was observed.

Conclusion

These children are at high risk for tooth developmental abnormalities and poor dental health and should be closely monitored by a specialist dentist.

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Publication date:

June /2022

Keywords:

Adverse effects, Anomalies, Caries dental, Malignancies

Issue:

Vol.23 – n.2/2022

Page:

131 – 136

Publisher:

Ariesdue

Topic:

Children with special health care needs

Cite:


Harvard: R. Guagnano, F. Romano, M. Berger, F. Fagioli, V. Vallone, L. Bello, M. C. Vitale, P. Defabianis (2022) "Long-term effect of anticancer therapy on dentition of Italian children in remission from malignant disease: A cross-sectional study", European Journal of Paediatric Dentistry, 23(2), pp131-136. doi: 10.23804/ejpd.2022.23.02.11
Vancouver: R. Guagnano, F. Romano, M. Berger, F. Fagioli, V. Vallone, L. Bello, M. C. Vitale, P. Defabianis. Long-term effect of anticancer therapy on dentition of Italian children in remission from malignant disease: A cross-sectional study. European Journal of Paediatric Dentistry [Internet]. 2022Jun.20 [cited 2025May.12];23(2):131-136. Available from: https://www.ejpd.eu/abstract-pubmed/long-term-effect-of-anticancer-therapy-on-dentition-of-italian-children-in-remission-from-malignant-disease-a-cross-sectional-study/
MLA: R. Guagnano, F. Romano, M. Berger, F. Fagioli, V. Vallone, L. Bello, M. C. Vitale, P. Defabianis Long-term effect of anticancer therapy on dentition of Italian children in remission from malignant disease: A cross-sectional study. European Journal of Paediatric Dentistry. 2022;23(2):131-136

Copyright (c) 2021 Ariesdue

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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    Editor in chief: dott. Luigi Paglia
    European Journal of Paediatric Dentistry © | ISSN (Online): 2035-648X
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    European Journal of Paediatric Dentistry © | ISSN (Online): 2035-648X
    Registrazione del Tribunale di Milano n. 285 del 14.04.1998 | ROC 1946 - 26.09.2001
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