To evaluate the effects of novel casein phosphopeptide (CPP) formulations CPP-amorphous calcium phosphate (CCP-
ACP) and CPP-amorphous calcium fluoride phosphate (CPP-ACFP) versus fluoride varnish on the remineralisation of enamel white
spot lesions (WSLs) over a 12-week follow-up period.
Study Design: Double-blind prospective study.
Eligibility criteria were patients between 6 and 14 years old and have WSLs on their permanent teeth. We evaluated 786 WSLs.
Participants were divided randomly into three groups. Groups A and B were instructed to daily topical application of GC Tooth Mouse
(CPP-ACP) or Mi Paste Plus (CPP-ACFP), Group C received a monthly professional application of Duraphat fluoride varnish. WSLs
were categorised according to the International Caries Detection and Assessment System (ICDAS II; grades 0-3) and assessed by
laser fluorescence (DIAGNOdent) at baseline and at 4, 8 and 12 weeks. Changes in mineralisation before and after treatment were
analysed using two-way analysis of variance, with post hoc Bonferroni's non-parametric tests for multiple comparisons.
DIAGNOdent values were significantly reduced in Group B at 4 weeks, and in Groups A and C at 8 weeks. Mean values in Group B
were lower than in Groups A and C at 4 weeks, and lower than Group C at 8 weeks. CPP-ACFP appeared to have a specific effect on
smooth-surface caries, but no significant effect on caries in pits and fissures.
At 4 weeks, CPP-ACFP is superior to
fluoride varnish at remineralising smooth-surface WSLs. CPP-ACP is not superior to fluoride varnish by any of the measures
Vol.16 – n.3/2015
Harvard: C. Llena, A. M. Leyda, L. Forner (2015) "CPP-ACP and CPP-ACFP versus fluoride varnish in remineralisation of early caries lesions. A prospective study", European Journal of Paediatric Dentistry, 16(3), pp181-186. doi: https://www.ejpd.eu/pdf/EJPD_2015_3_2.pdf
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