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Home Comparison of oral Midazolam and Midazolam-Ketamine as sedative agents in paediatric dentistry

Comparison of oral Midazolam and Midazolam-Ketamine as sedative agents in paediatric dentistry

Authors:

  • E. Cagiran
    Ege University Faculty of Medicine Anestesiology Dept, Izmir, Turkey
  • C. Eyigor
    Ege University Faculty of Medicine Anestesiology Dept, Pain Clinic, Izmir, Turkey
  • A. Sipahi
    Ege University Faculty of Dentistry Oral and maxillofacial Surgery Dept, Izmir, Turkey
  • H. Koca
    Associate Professor, Ege University Faculty of Dentistry Oral and maxillofacial Surgery Dept, Izmir, Turkey
  • T. Balcioglu
    Professor, Ege University Faculty of Medicine Anestesiology Dept, Izmir, Turkey
  • M. Uyar
    Professor, Ege University Faculty of Medicine Anestesiology Dept, Pain Clinic, Izmir, Turkey

ABSTRACT


Aim

We compared the efficacy of sedation with oral Midazolam and a combination of oral Midazolam and
Ketamine, used as alternatives to general anaesthesia during tooth extraction. Study Design: Retrospective study.

Methods

A total of 30 patients aged between 3 and 9 years, who had elective tooth extraction were
included in the study. Subjects in Group A (n. 15) were given 0.75 mg/kg Midazolam orally while those in Group B (n. 15)
were given 0.75 mg/kg Midazolam orally + 5 mg/kg ketamine. Acceptance of orally administered drugs, sedation and anxiety
scores and reactions to local anaesthetic injection and tooth extraction were assessed.

Results

Sedation and anxiety
scores in Group B were better than in Group A (p<0.05). Reactions to local anaesthetic injection and tooth extraction were very significantly less common in Group B (p<0.0001). Requirement for an additional medication was more common in Group A (p<0.05). Side effects were not observed in either group. Statistics: Patient demographics and time to discharge were analysed by Mann-Whitney U test, whereas Chi-square test was used to analyse compliance to sedation, anxiety and sedation scores, reaction to tooth extraction, side effects and additional drug requirement.

Conclusion

Compared to oral
Midazolam only, a combination of oral Midazolam+Ketamine resulted in better sedation and surgical comfort in children
during a painful procedure such as tooth extraction.

PLUMX METRICS

Publication date:

Mar /2010

Keywords:

ketamine, midazolam, oral sedation, paediatric dentistry

Issue:

Vol.11 – n.1/2010

Page:

19 – 22

Publisher:

Ariesdue

Cite:


Harvard: E. Cagiran, C. Eyigor, A. Sipahi, H. Koca, T. Balcioglu, M. Uyar (2010) "Comparison of oral Midazolam and Midazolam-Ketamine as sedative agents in paediatric dentistry", European Journal of Paediatric Dentistry, 11(1), pp19-22. doi:
Vancouver: E. Cagiran, C. Eyigor, A. Sipahi, H. Koca, T. Balcioglu, M. Uyar. Comparison of oral Midazolam and Midazolam-Ketamine as sedative agents in paediatric dentistry. European Journal of Paediatric Dentistry [Internet]. 2010Mar.1 [cited 2025Jun.22];11(1):19-22. Available from: https://www.ejpd.eu/abstract-pubmed/comparison-of-oral-midazolam-and-midazolam-ketamine-as-sedative-agents-in-paediatric-dentistry/
MLA: E. Cagiran, C. Eyigor, A. Sipahi, H. Koca, T. Balcioglu, M. Uyar Comparison of oral Midazolam and Midazolam-Ketamine as sedative agents in paediatric dentistry. European Journal of Paediatric Dentistry. 2010;11(1):19-22

Copyright (c) 2021 Ariesdue

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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    European Journal of Paediatric Dentistry © | ISSN (Online): 2035-648X
    Registrazione del Tribunale di Milano n. 285 del 14.04.1998 | ROC 1946 - 26.09.2001
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