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Home Chloral hydrate for sedation of children with asthma during dental treatment

Chloral hydrate for sedation of children with asthma during dental treatment

Authors:

  • I. Abdulhamid
    Department of Developmental Dentistry, Children's Hospital of Michigan, Wayne State University, Detroit, USA
  • M. Tremblay
    Pulmonary Medicine Division and Pediatric Sleep Laboratory, Wayne State University, Detroit, USA
  • J. Stenger
    Pulmonary Medicine Division and Pediatric Sleep Laboratory, Wayne State University, Detroit, USA
  • V. Tutag Lehr
    The Eugene Applebaum College of Pharmacy and Health Sciences, Department of Pharmacy Practice

ABSTRACT


Aim

We hypothesised that chloral hydrate is safe and effective for sedation during dental treatments for children with mild
asthma. We evaluated the safety and efficacy of chloral hydrate by measuring changes in heart rate (HR), transcutaneous oxygen
saturation, (SpO2), asthma score, behaviour, types and frequency of adverse reactions associated with chloral hydrate were assessed
throughout treatment.

Methods

Children (<10 years old) with mild asthma undergoing dental treatments received a single 65 mg/kg oral dose of chloral hydrate liquid 1 hour prior to treatment in an open label trial. Heart rate (HR), SpO2, asthma score, behaviour, types and frequency of adverse reactions associated with chloral hydrate were assessed throughout treatment. Asthma score was obtained before and after treatment. Thirty minutes after treatment, SpO2, HR, and level of consciousness was assessed.

Results

Twenty four children were enrolled and 92 (22/24) recovered from sedation without respiratory
depression. Two experienced mild respiratory depression related to chloral hydrate. Asthma was not a contributing factor as they did not
experience wheezing, cough, tachypnoea, or retractions. Inhaled nitrous oxide supplemented chloral hydrate sedation in 63
(15/24) children to achieve effective cooperation. Three children had a SpO2 <95 (2 during treatment, 1 during recovery).

Conclusion

Chloral hydrate 65 mg/kg administered a as single oral dose appears to be safe with respect to disease exacerbation
for children with mild asthma undergoing dental treatment. Due to ineffective sedation and mild respiratory depression associated with
chloral hydrate, newer, easily titrated medications, such as midazolam, may offer advantages.

PLUMX METRICS

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Publication date:

Jun /2016

Keywords:

asthma, children, chloral hydrate, dental treatment

Issue:

Vol.17 – n.2/2016

Page:

141 – 146

Publisher:

Ariesdue

Cite:


Harvard: I. Abdulhamid, M. Tremblay, J. Stenger, V. Tutag Lehr (2016) "Chloral hydrate for sedation of children with asthma during dental treatment", European Journal of Paediatric Dentistry, 17(2), pp141-146. doi: https://www.ejpd.eu/wp-content/uploads/pdf/EJPD_2016_2_9.pdf
Vancouver: I. Abdulhamid, M. Tremblay, J. Stenger, V. Tutag Lehr. Chloral hydrate for sedation of children with asthma during dental treatment. European Journal of Paediatric Dentistry [Internet]. 2016Jun.1 [cited 2023Jan.27];17(2):141-146. Available from: https://www.ejpd.eu/abstract-pubmed/chloral-hydrate-for-sedation-of-children-with-asthma-during-dental-treatment/
MLA: I. Abdulhamid, M. Tremblay, J. Stenger, V. Tutag Lehr Chloral hydrate for sedation of children with asthma during dental treatment. European Journal of Paediatric Dentistry. 2016;17(2):141-146

Copyright (c) 2021 Ariesdue

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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