The purpose of this pilot study was to identify the subsurface enamel demineralising potential of two possible acidogenic
lactose-based powders and their corresponding generic pump inhalers.
Ten healthy non-asthmatic adults participated in a 5-leg randomised crossover study including a 10 sucrose control. A twice-daily 400 g dose of inhaler was applied in vitro to a demineralised enamel slab on the buccal flange of a mandibular removable appliance before in situ placement for 14 days each.
Lesion parameters were determined using transverse microradiography and digitised image analysis.
Minimal demineralisation occurred with sucrose, both pump and one powder inhaler. The remaining powder was associated with remineralisation (p = 0.29). Overall, mean lesion depth increased (p = 0.12).
Asthma inhalers failed to demonstrate a significant acidogenic/cariogenic effect.
Vol.6 – n.3/2005
Harvard: R. Tootla, G. Kotru, M. A. Connolly, M. S. Duggal, K. J. Toumba (2005) "Asthma inhalers and subsurface enamel demineralisation: an in situ pilot study", European Journal of Paediatric Dentistry, 6(3), pp139-143. doi:
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