A Systematic Review and Meta-analysis of Regenerative Pulpotomy in the Treatment of Vital Primary Teeth

Authors:

N. T. Snigdha
Department of Dental Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 602105, Tamil Nadu, India. - Paediatric Dentistry Unit, School of Dental Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia.
M. I. Karobari
Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, Tamil Nadu, India
A. Kamarudin
Paediatric Dentistry Unit, School of Dental Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia.
N. A. Samsudin
Paediatric Dentistry Unit, School of Dental Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia.
F. Baharin
Paediatric Dentistry Unit, School of Dental Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian 16150, Kelantan, Malaysia.
N. Dziaruddin
Department of Paediatric Dentistry and Orthodontics, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia.
A. A. Assiry
Preventive Dental Science Department, Faculty of Dentistry, Najran University, Kingdom of Saudi Arabia.
A. M. Luke
Department of Clinical Sciences, College of Dentistry, Ajman University, Ajman, UAE. - Center for Medical and Bio-Allied Health Sciences Research (CMBAHSR), Ajman University, Ajman, UAE
G. A. Scardina
Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.) University of Palermo Italy.

DOI:

https://doi.org/10.23804/ejpd.2024.1981

ABSTRACT

Aim

To assess the clinical and radiographic success rates of regenerative pulpotomy compared to devitalising or preservative pulpotomy in treating vital pulp exposure in primary teeth.

Methods

Comprehensive search with PubMed/MEDLINE, Cochrane Library, Web of Science, Google Scholar and Open Grey databases was done and two reviewers extracted the data after assessing the studies for eligibility criteria. The Cochrane Collaboration Tool and Minors Checklist assessed the quality of the selected studies. A meta-analysis was performed using RevMan (P<0.05).

Results

Forty-nine articles were included for qualitative synthesis, of which, 44 were included in the meta-analysis. The authors found no significant differences between the clinical and radiographic failure rates of Mineral trioxide aggregate (MTA) versus formecresol (FC). MTA resulted in a success rate of 1.01 (95% CI: 0.99–1.03), 1.09 (95% CI: 0.99–1.21), 1.02 (95% CI: 0.99–1.05), 1.01(95% CI: 0.98–1.04), and 1.04-fold (95% CI: 0.97–1.11) higher than that for FC. The radiographic success rate showed a statistically significant difference favouring MTA and Ferric Sulphate comparison with a 1.2-fold (95% CI: 1.05–1.43) higher radiographic success rate for MTA at 24-months follow-up. The radiographic or clinical failure rates of Biodentine (BD) and FC or of BD and FS or CH and FC showed no substantial differences. At 6 months follow-up, BD showed 9.253-fold higher radiographic success rate as compared to FC showing a statistically significant difference (RR, 9.253, 95% CI: 1.62–55.98). Further, 24 months follow-up, CH showed 0.85-fold lower radiographic success rate as compared to FC showing a statistically significant difference (RR, 0.85 95% CI: 0.73–0.98).

Conclusion

Within the limitations of the study, it can be concluded that MTA seemed to be the better alternative to FC and FS, showing a lower risk of failure and can be recommended for pulpotomy in primary teeth. BD also demonstrated promising results as a pulpotomy medicament.

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Publication date:

September /2024

Publisher:

Tecniche Nuove

Topic:

Pulp therapy for primary & young permanent teeth

Cite:

Harvard: N. T. Snigdha, M. I. Karobari, A. Kamarudin, N. A. Samsudin, F. Baharin, N. Dziaruddin, A. A. Assiry, A. M. Luke, G. A. Scardina (2024) "A Systematic Review and Meta-analysis of Regenerative Pulpotomy in the Treatment of Vital Primary Teeth", European Journal of Paediatric Dentistry, (), pp1-. doi: 10.23804/ejpd.2024.1981

Vancouver: N. T. Snigdha, M. I. Karobari, A. Kamarudin, N. A. Samsudin, F. Baharin, N. Dziaruddin, A. A. Assiry, A. M. Luke, G. A. Scardina. A Systematic Review and Meta-analysis of Regenerative Pulpotomy in the Treatment of Vital Primary Teeth. European Journal of Paediatric Dentistry [Internet]. 2024Sep.20 [cited 2025Dec.05];():1-. Available from: https://www.ejpd.eu/abstract-pubmed/a-systematic-review-and-meta-analysis-of-regenerative-pulpotomy-in-the-treatment-of-vital-primary-teeth/

MLA: N. T. Snigdha, M. I. Karobari, A. Kamarudin, N. A. Samsudin, F. Baharin, N. Dziaruddin, A. A. Assiry, A. M. Luke, G. A. Scardina A Systematic Review and Meta-analysis of Regenerative Pulpotomy in the Treatment of Vital Primary Teeth. European Journal of Paediatric Dentistry. 2024;():1-

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